I will keep this short because I may be missing the point of the subject.
Location can be a character in a book. If it is real, and the character comes from that locale, then setting impacts character. For instance, I am a different person because I grew up in Canada rather than in the small town on the banks of Lake Washington where my parents lived after I was born.
If the place is fictional, whether in mystery or science fiction or fantasy, locale and character reflect each other. Either the place is created to impact the character or the character is formed to impact the place. Both are fictional. Both come from the mind of the same person. So, to my mind, fictional real estate says less about my character than both speak to my purpose in writing the book.
Now I can read what the other LadyKillers have said!